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Autoantibody target...
Autoantibody targets in vaccine-associated narcolepsy
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- Häggmark-Månberg, Anna (author)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab
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- Zandian, Arash (author)
- KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Forsström, Björn (author)
- KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Khademi, Mohsen (author)
- Karolinska Institutet
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- Bomfim, Izaura Lima (author)
- Karolinska Institutet
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- Hellström, Cecilia (author)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab
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- Arnheim-Dahlström, Lisen (author)
- Karolinska Institutet
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- Hallböök, Tove (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Darin, Niklas (author)
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- Lundberg, Ingrid E. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Uhlén, Mathias (author)
- KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Partinen, Markku (author)
- University of Helsinki
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- Schwenk, Jochen M. (author)
- KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Olsson, Tomas (author)
- Karolinska Institutet
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- Nilsson, Peter (author)
- KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2016-05-20
- 2016
- English.
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In: Autoimmunity. - : Taylor & Francis. - 0891-6934 .- 1607-842X. ; 49:6, s. 421-433
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Narcolepsy is a chronic sleep disorder with a yet unknown cause, but the specific loss of hypocretin-producing neurons together with a strong human leukocyte antigen (HLA) association has led to the hypothesis that autoimmune mechanisms might be involved. Here, we describe an extensive effort to profile autoimmunity repertoires in serum with the aim to find disease-related autoantigens. Initially, 57 serum samples from vaccine-associated and sporadic narcolepsy patients and controls were screened for IgG reactivity towards 10 846 fragments of human proteins using planar microarrays. The discovered differential reactivities were verified on suspension bead arrays in the same sample collection followed by further investigation of 14 antigens in 176 independent samples, including 57 narcolepsy patients. Among these 14 antigens, methyltransferase-like 22 (METTL22) and 5'-nucleotidase cytosolic IA (NT5C1A) were recognized at a higher frequency in narcolepsy patients of both sample sets. Upon sequence analysis of the 14 proteins, polymerase family, member 3 (PARP3), acyl-CoA-binding domain containing 7 (ARID4B), glutaminase 2 (GLS2) and cyclin-dependent kinase-like 1 (CDKL1) were found to contain amino acid sequences with homology to proteins found in the H1N1 vaccine. These findings could become useful elements of further clinical assays that aim towards a better phenotypic understanding of narcolepsy and its triggers.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Narcolepsy
- autoantibody
- vaccine-associated
- protein microarray
- serum
- autoantibody
- Narcolepsy
- protein microarray
- serum
- vaccine-associated
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Häggmark-Månberg ...
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Zandian, Arash
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Forsström, Björn
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Khademi, Mohsen
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Bomfim, Izaura L ...
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Hellström, Cecil ...
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show more...
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Arnheim-Dahlströ ...
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Hallböök, Tove
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Darin, Niklas
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Lundberg, Ingrid ...
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Uhlén, Mathias
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Partinen, Markku
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Schwenk, Jochen ...
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Olsson, Tomas
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Nilsson, Peter
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Autoimmunity
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Lund University